Purpose: There is an increasing predilection to obesity and consequent Cardiovascular Diseases (CVD) among women. This study investigated knowledge of Nigerian female undergraduates on obesity as a risk factor for CVD in women. Participants: 400 female undergraduate students from the Obafemi Awolowo University, Ile-Ife, Nigeria participated in this study. Methods: This cross-sectional study used a self-developed questionnaire to assess respondents’ socio-demographic variables and knowledge of obesity as a risk factor for CVD. The questionnaire was tested in a pilot study using a test retest reliability method: Descriptive statistics and spearman rank correlation were used for data analysis. Alpha level was set at 0.05. Results: Excessive high calorie intake, 322(80.5%), fatty food intake, 393(98.3%) and physical inactivity, 360(90.0%) were the most implicated causative factors for obesity. Three hundred and thirty five, 83.8% of the respondents recognized obesity as a leading cause of heart attack. More than half, 242(60.5%) of the respondents identified obesity as a risk factor for CVD. There was no significant correlation between knowledge score of obesity as a risk factor for CVD and each of age (r = -0.045; p = 0.367), level of study (r = 0.037; p = 0.456) and source of information (r = -0.005; p = 0.923). Conclusion: Nigerian female undergraduates demonstrated fair knowledge of obesity as a risk factor for cardiovascular diseases in women and knowledge was not significantly influenced by age, level of study and source of information.  Implication: Obesity is a public health issue and adequate knowledge may help reduce prevalence of cardiovascular disease.